Welcome on board, Budi ! We are pleased to announce that Budi Octasari Susanto is now a member of the Calvagone Team. We are very happy to have her in our team of consultants.

Welcome on board, Sarah ! We are pleased to announce that Sarah Lobet is now a member of the Calvagone Team. We are very happy to have her in our team of consultants.

Meet us at PAGE 2022 in Ljubljana! Andreas, Christian, Emilie, Erno and Nicolas will be at PAGE in Ljubljana from June 28 to July 1st. You can meet us at the venue, during poster session on Wednesday morning (I-32) or contact us directly to schedule a meeting. contact@calvagone.com

Focus on Calvagone: interview on BFM Business Christian was interviewed on BFM Business, in « l’hebdo des PME ». To present Calvagone, its roles in pharmacometrics, supporting our clients in clinical drug development. The video (in French) is available here! https://youtu.be/Sv2RpRP5BNU

CAMPSIS is available on CRAN! We are very pleased to share with you CAMPSIS, an open-source PK-PD simulation platform running in R based on RxODE and mrgsolve engines.Available for download on CRAN!Please visit https://www.campsis.org, or contact us for more information.

Welcome on board, Nicolas ! We are pleased to announce that Nicolas Luycks is now a member of the Calvagone Team. We are very happy to have him in our team of consultants.

Welcome on board, Stéphanie ! We are pleased to announce that Stéphanie Blaizot-Besse is now a member of the Calvagone Team. We are very happy to have her in our team of consultants.

Meet us at PAGE 2019 in Stockholm! Andreas, Christian, Emilie, Erno and Philippe will be at PAGE in Stockholm from June 11 to 14. You can meet us at the venue, during poster sessions on Wednesday afternoon (II-77) and Thursday afternoon (IV-46) or contact us directly to schedule a meeting. contact@calvagone.com

4th European course on Pharmacokinetics and Pharmacodynamics of Protein Therapeutics. November 20-22 2019. Lyon, France Information & Registration Form   After a great success of the 3rd edition in November 2018, AP2POP association is organising a 4th European course, November 20-22 2019 in Lyon. This 3-day course will introduce participants to basic principles in the pharmacokinetics and pharmacodynamics of novel therapeutic proteins and provide opportunities for basic hands-on exercises in the PK/PD evaluation of these compounds. Topics include target-mediated drug disposition, tissue and tumor penetration, first-in-human dose selection, immunogenicity, clinical pharmacology challenges, biosimilars, and drug-drug interactions. Hands-on exercises and simulations will be performed individually and in small groups using simple software tools (no prior experience required). The course is a shortened version of the week-long course on « Pharmacokinetics and Pharmacodynamics of Protein Therapeutics – Concepts and Hands-On Modeling and Simulation » that Drs. Meibohm and Gabrielsson have offered for the last nine years in the United States. Christian, Philippe and Emilie are happy to host this course in Lyon.

Welcome on Board Andreas ! We are pleased to announce that Andreas Lindauer is now a member of the Calvagone Team. We are very happy to have him in our team of consultants.

Oral presentation at LAI conference, February 7-8 2019 Erno has been invited to present the work that was done in collaboration with Janssen R&D on paliperidone palmitate depot formulations at the Long-Acting Injectables and Implantables conference held in Beerse and Leuven, Belgium on 7 and 8 February 2019. The title of the presentation is: « Towards a generic, mechanism-based model to predict in vivo PK behaviour for LAI nano-/microsuspensions ». The conference intended to provide insights to the clinical applications and benefits for the patients, the available technologies and recent development, how to use advanced pharmacokinetic modelling in the definition of the formulation, … More information on the event can be found here.

Calvagone team in Shanghai Christian, Erno and Emilie have given a 4-day NONMEM basic training in Shanghai. Participants gave very positive feedback, and are eager to learn even more!… « This is a course to show the thinking on best practice of population approach to modelling your data. It combines the level of details of some statistics (just about the right information) and pharmacometrics, which is unique to other class/projects that I have experienced. » « I feel really great about this training and know much more about the fundamental thinking behind the technical things. » « I like the course atmosphere which is full of discussion. What is more, I love hands-on sessions, if we have more time I suggest that we could practice more. »

Presentation at BioTuesdays Calvagone has been invited to present the company and its activity to the BioTuesday event, in September 2018. BioTuesday gather, each month, the actors in Lyon area in the research field of Health and Life Sciences. More information on upcoming events can be found here. Slides of Calvagone presentation

Meet us at PAGE 2018 in Montreux! Christian, Emilie, Erno and Philippe will be at PAGE in Montreux from May 28 to June 1. You can meet us at the venue, during poster sessions on Wednesday morning (I-45), Wednesday afternoon (II-40) and Thursday afternoon (IV-03 and IV-58) or contact us directly to schedule a meeting. contact@calvagone.com

3rd European course on Pharmacokinetics and Pharmacodynamics of Protein Therapeutics. November 28-30 2018. Lyon, France Information & Registration Form   This 3-day course will introduce participants to basic principles in the pharmacokinetics and pharmacodynamics of novel therapeutic proteins and provide opportunities for basic hands-on exercises in the PK/PD evaluation of these compounds. Topics include target-mediated drug disposition, tissue and tumor penetration, first-in-human dose selection, immunogenicity, clinical pharmacology challenges, biosimilars, and drug-drug interactions. Hands-on exercises and simulations will be performed individually and in small groups using simple software tools (no prior experience required). The course is a shortened version of the week-long course on « Pharmacokinetics and Pharmacodynamics of Protein Therapeutics – Concepts and Hands-On Modeling and Simulation » that Drs. Meibohm and Gabrielsson have offered for the last eight years in the United States. Christian and Emilie are happy to host this course in Lyon.

Meet us at PAGE 2017 in Budapest! Erno and Christian will be at PAGE in Budapest from June 6 to 9. You can meet us at the venue, during poster sessions on Wednesday afternoon (II-44) and Thursday morning (III-62) or contact us directly to schedule a meeting. contact@calvagone.com

2nd European course on Pharmacokinetics and Pharmacodynamics of Protein Therapeutics. Principle and Pharmacometric Approaches. August 29-31, 2017, Darmstadt, Germany. Registration   This second 3-day course will introduce participants to basic principles in the pharmacokinetics and pharmacodynamics of novel therapeutic proteins and provide opportunities for basic hands-on exercises in the PK/PD evaluation of these compounds. Topics include target-mediated drug disposition, tissue and tumor penetration, first-in-human dose selection, immunogenicity, clinical pharmacology challenges, biosimilars, and drug-drug interactions. Hands-on exercises and simulations will be performed individually and in small groups using simple software tools (no prior experience required). The course is a shortened version of the week-long course on ‘Pharmacokinetics and Pharmacodynamics of Protein Therapeutics – Concepts and Hands-On Modeling and Simulation’ that Drs. Meibohm and Gabrielsson have offered for the last seven years in the United States. Christian will co-host this course together with Pascal Girard and Maike Puetter from Merck.

Welcome on Board Philippe ! We are pleased to announce that Philippe Pierrillas is now a member of the Calvagone Team. Philippe received his PhD training from the University of Lyon and is joining us upon completion of a postdoctoral research period at the Pharmacometrics Research Group in Uppsala, Sweden, where he worked closely with Professors Mats Karlsson, Lena Friberg and Andy Hooker. We are very happy to have him in our team of consultants.

We obtained Crédit Impôt Recherche (CIR) accreditation On April 3 2017, we received Crédit Impôt Recherche (CIR) accreditation from the French Ministère de la Recherche for the period 2017 up to 2019. CIR is a French governmental initiative to promote partnership between companies on Research and Development oriented projects. If you want to read more, please visit: https://www.service-public.fr/professionnels-entreprises/vosdroits/F23533

Kick-Off Meeting for DDMoRe Foundation on 17th of January 16:30 (CET) The DDMoRe Foundation will initiate 3 Community groups to facilitate community initiatives to support developement of: – Languages: progress the standards (MDL, PharmML, SO and Prov-O) – Model Repository: enhance the repository content and improve the suer experience – Thoughtflow: take the proof of concept ot the next level You are very welcome to participate to this Kick-Off Meeting !

Welcome on Board Erno ! We are very pleased to announce that Erno van Schaick is now a member of the Calvagone Team.

Clinical Trial Simulation Training at Lyon University In collaboration with Exprimo (Ruben Faelens), a 2-hour session in Clinical Trial Simulation was organized at Lyon University as part of the Master’s program curated by Emilie. The 10 students managed to explore the PK model for Sunitinib. Four students struck gold at the end, managing to create an efficient design that proved biosimilarity.

nlmxr is an open-source R package for population PK/PD modelling developped by Wenping Wang and Yuan Xiong, in collaboration with Occams (Rik Schoemaker and Justin Wilkins).Christian, at that time as an Exprimo member, has built a bunch of simulated datasets from a large panel of PK and PK/PD models and some of them were used to challenge nlmxr.