This 3-day course will introduce participants to basic principles in the pharmacokinetics and pharmacodynamics of novel therapeutic proteins and provide opportunities for basic hands-on exercises in the PK/PD evaluation of these compounds. Topics include target-mediated drug disposition, tissue and tumor penetration, first-in-human dose selection, immunogenicity, clinical pharmacology challenges, biosimilars, and drug-drug interactions. Hands-on exercises and simulations will be performed individually and in small groups using simple software tools (no prior experience required).
The course is a shortened version of the week-long course on « Pharmacokinetics and Pharmacodynamics of Protein Therapeutics – Concepts and Hands-On Modeling and Simulation » that Drs. Meibohm and Gabrielsson have offered for the last eight years in the United States. Christian and Emilie are happy to host this course in Lyon.